Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043181 | 0.83 | ADRB2 (0.52) | ALDH1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL16812994 | 0.82 | HRH4 (0.55) | CHRM2HRH4HRH3 | |
| SCHEMBL13903744 | 0.81 | HDAC3 (0.66) | ALDH1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL16730575 | 0.81 | HDAC3 (0.66) | ALDH1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5048135 | 0.81 | ALDH1A1 (0.47) | ALDH1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19438874 | 0.80 | HDAC3 (0.65) | ALDH1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2995431 | 0.79 | LMNA (0.52) | ALDH1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5046740 | 0.78 | HDAC1 (0.44) | HDAC3HDAC1HDAC2HDAC8SMN1; SMN2 | |
| SCHEMBL5049415 | 0.76 | S1PR1 (0.63) | HDAC3HDAC1HDAC2HDAC8SMN1; SMN2 | |
| SCHEMBL5046386 | 0.76 | ALDH1A1 (0.44) | ALDH1A1HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |