Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14278707 | 0.89 | SMN1; SMN2 (0.37) | PLA2G7POLBSMN1; SMN2SCN9ATSHR | |
| SCHEMBL5038310 | 0.89 | SMN1; SMN2 (0.37) | PLA2G7POLBSMN1; SMN2SCN9ATSHR | |
| SCHEMBL5033952 | 0.77 | RAB9A (0.46) | PLA2G7POLBSMN1; SMN2TSHRRAB9A | |
| SCHEMBL5041304 | 0.75 | RAB9A (0.38) | PLA2G7POLBSMN1; SMN2SCN9ARAB9A | |
| SCHEMBL14278748 | 0.74 | NOD2 (0.42) | SMN1; SMN2TSHRRAB9AKMT2ATP53 | |
| SCHEMBL5042461 | 0.72 | CYP1A2 (0.47) | POLBSMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL2089517 | 0.63 | KMT2A (0.52) | PLA2G7SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL4635029 | 0.62 | ALPL (0.45) | PLA2G7POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4635031 | 0.62 | ALPL (0.45) | PLA2G7POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6185781 | 0.62 | RAB9A (0.53) | PLA2G7POLBSMN1; SMN2RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660487-B1 | PYRROLE COMPOSITIONS USEFUL AS INHIBITORS OF C-MET | VERTEX PHARMA (US) | 2008-03-19 | — | — | EP | disclosed |