Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 10/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28746051 | 0.95 | TAS2R14 (0.50) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL5046594 | 0.91 | TAS2R14 (0.54) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL5043193 | 0.87 | TAS2R14 (0.56) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL5046383 | 0.85 | PTGER2 (0.59) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL5046836 | 0.81 | TAS2R14 (0.53) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL5050266 | 0.81 | TAS2R14 (0.49) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL27537714 | 0.81 | TAS2R14 (0.54) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL5048109 | 0.79 | TAS2R14 (0.69) | TAS2R14MEN1KMT2A | |
| SCHEMBL6059002 | 0.79 | ALDH1A1 (0.60) | TAS2R14CA12CA1CA2CA4 | |
| SCHEMBL5046892 | 0.79 | PTGER2 (0.57) | CA12CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| CN-1211367-C | Prostaglandin agonists and their use to treat bone disorders | PFIZER (US) | 2005-07-20 | — | — | CN | disclosed |
| CN-1566096-A | Prostaglandin agonists and their use to treat bonedisorders | PFIZER (US) | 2005-01-19 | — | — | CN | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| CN-1275123-A | Prostaglandin agonists and their use to treat bone disorders | PFIZER (US) | 2000-11-29 | — | — | CN | disclosed |