Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048109 | 0.94 | TAS2R14 (0.69) | ALDH1A1TAS2R14MAPTLMNAPTGES | |
| SCHEMBL5042984 | 0.90 | TAS2R14 (0.56) | ALDH1A1TAS2R14MAPTLMNAGAA | |
| SCHEMBL5133321 | 0.89 | FABP4 (0.49) | ALDH1A1TAS2R14MAPTLMNAGAA | |
| SCHEMBL5048105 | 0.86 | ALDH1A1 (0.49) | ALDH1A1TAS2R14MAPTLMNAGAA | |
| SCHEMBL5043270 | 0.86 | TAS2R14 (0.64) | ALDH1A1TAS2R14MAPTPTGESALOX5 | |
| SCHEMBL5048100 | 0.84 | TAS2R14 (0.64) | ALDH1A1TAS2R14MAPTLMNAPTGES | |
| SCHEMBL5043193 | 0.82 | TAS2R14 (0.56) | TAS2R14PTGESALOX5CA12CA1 | |
| SCHEMBL14569572 | 0.82 | PTGDR2 (0.52) | ALDH1A1MAPTLMNAGAAHPGD | |
| SCHEMBL5043143 | 0.81 | KMT2A (0.51) | ALDH1A1TAS2R14MAPTGAANPSR1 | |
| SCHEMBL14558104 | 0.81 | PTGDR2 (0.49) | ALDH1A1MAPTLMNAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |