Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043788 | 0.79 | L3MBTL1 (0.48) | L3MBTL1MAPK1CREBBPMKNK1MKNK2 | |
| SCHEMBL1366828 | 0.74 | L3MBTL1 (0.56) | L3MBTL1MAPK1CREBBPMKNK1MKNK2 | |
| SCHEMBL2063286 | 0.72 | KCNA5 (0.64) | L3MBTL1MAPK1CREBBPPDK2 | |
| SCHEMBL4784136 | 0.70 | L3MBTL1 (0.60) | L3MBTL1MAPK1CREBBPPIK3CDPDK2 | |
| SCHEMBL5149370 | 0.68 | LTA4H (0.44) | L3MBTL1MAPK1 | |
| SCHEMBL884904 | 0.66 | KCNA5 (0.57) | L3MBTL1CREBBPALDH1A1 | |
| SCHEMBL17646086 | 0.64 | KDR (0.51) | MAPK1ALDH1A1ABL1 | |
| SCHEMBL21937939 | 0.64 | CREBBP (0.77) | L3MBTL1CREBBPALK | |
| SCHEMBL21045462 | 0.64 | HDAC3 (0.54) | L3MBTL1 | |
| SCHEMBL10094644 | 0.64 | CREBBP (0.69) | L3MBTL1CREBBPPIK3CDPDK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |