Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044189 | 0.94 | FFAR1 (0.47) | MAPK14HPGDLMNASMN1; SMN2HTT | |
| SCHEMBL5044851 | 0.89 | MAPK14 (0.49) | MAPK14HPGDPPARGPPARAEPHX2 | |
| SCHEMBL1859045 | 0.87 | STAT3 (0.46) | MAPK14HPGDPPARGPPARAEPHX2 | |
| SCHEMBL5047479 | 0.87 | MAPK14 (0.47) | MAPK14HPGDPPARGPPARAEPHX2 | |
| SCHEMBL5044898 | 0.85 | EPHX2 (0.51) | HPGDPPARGPPARAEPHX2SMN1; SMN2 | |
| SCHEMBL5044185 | 0.84 | FFAR1 (0.46) | MAPK14HPGDPPARGPPARAEPHX2 | |
| SCHEMBL6023308 | 0.83 | MAPK14 (0.51) | MAPK14HPGDPPARGPPARAEPHX2 | |
| SCHEMBL5040011 | 0.83 | FFAR1 (0.48) | MAPK14HPGDLMNASMN1; SMN2HTT | |
| SCHEMBL1855452 | 0.83 | PTGES (0.42) | MAPK14HPGDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6022102 | 0.82 | LSS (0.47) | MAPK14PPARGPPARAEPHX2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |