Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | GLI1 | P08151 | 1/20 | 0.38 |
| ▸ | GLI2 | P10070 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044266 | 0.83 | LTA4H (0.48) | LTA4HEPHX2NPC1RAB9AKDM4E | |
| SCHEMBL5048336 | 0.79 | NAAA (0.41) | NPC1RAB9A | |
| SCHEMBL1852654 | 0.79 | LTA4H (0.45) | LTA4HEPHX2NPC1RAB9AKDM4E | |
| SCHEMBL6022090 | 0.79 | GLI1 (0.43) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL5043892 | 0.79 | GLI1 (0.43) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL5044001 | 0.78 | MEN1 (0.42) | LTA4HEPHX2NPC1RAB9AMEN1 | |
| SCHEMBL6022041 | 0.76 | NPC1 (0.47) | LTA4HEPHX2NPC1RAB9AKDM4E | |
| SCHEMBL5047813 | 0.75 | MEN1 (0.46) | LTA4HEPHX2NPC1RAB9AMEN1 | |
| SCHEMBL5044120 | 0.74 | MEN1 (0.42) | LTA4HEPHX2NPC1RAB9AALDH1A1 | |
| SCHEMBL1857107 | 0.73 | MEN1 (0.44) | LTA4HEPHX2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |