Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NAAA | Q02083 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 7/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045529 | 0.89 | TRPV1 (0.60) | HDAC6NAAASMN1; SMN2TRPV1PTAFR | |
| SCHEMBL5041082 | 0.89 | NAAA (0.60) | KMT2ANAAASMN1; SMN2 | |
| SCHEMBL1855256 | 0.88 | EPHX2 (0.51) | HDAC2HDAC8HDAC6KMT2ANAAA | |
| SCHEMBL27619602 | 0.85 | TRPV1 (0.57) | HDAC2HDAC8HDAC6KMT2ANAAA | |
| SCHEMBL5039921 | 0.84 | SMN1; SMN2 (0.56) | HDAC8NAAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5040331 | 0.84 | SMN1; SMN2 (0.54) | HDAC8NAAASMN1; SMN2 | |
| SCHEMBL5039987 | 0.83 | NAAA (0.51) | HDAC6KMT2ANAAASMN1; SMN2MEN1 | |
| SCHEMBL5044578 | 0.82 | SMN1; SMN2 (0.48) | KMT2ANAAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5044129 | 0.82 | MRGPRX4 (0.47) | HDAC2NAAASMN1; SMN2 | |
| SCHEMBL5044104 | 0.82 | SMN1; SMN2 (0.52) | HDAC8NAAASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |