Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 2/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047490 | 0.89 | MLYCD (0.53) | ALDH1A1SMN1; SMN2NAAAMLYCDHDAC3 | |
| SCHEMBL1850884 | 0.89 | NAAA (0.44) | MRGPRX4ALDH1A1POLBSMN1; SMN2NAAA | |
| SCHEMBL5044180 | 0.87 | MRGPRX4 (0.48) | MRGPRX4ALDH1A1POLBSMN1; SMN2NAAA | |
| SCHEMBL5044177 | 0.87 | MRGPRX4 (0.48) | MRGPRX4ALDH1A1POLBSMN1; SMN2NAAA | |
| SCHEMBL5044747 | 0.82 | HDAC2 (0.52) | SMN1; SMN2NAAAHDAC2 | |
| SCHEMBL5040331 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2NAAAHDAC3TMEM97SIGMAR1 | |
| SCHEMBL5041082 | 0.80 | NAAA (0.60) | SMN1; SMN2NAAAHDAC3NAMPTTMEM97 | |
| SCHEMBL5039921 | 0.80 | SMN1; SMN2 (0.56) | MRGPRX4SMN1; SMN2NAAAHDAC3NAMPT | |
| SCHEMBL5039987 | 0.79 | NAAA (0.51) | ALDH1A1POLBSMN1; SMN2NAAAHDAC3 | |
| SCHEMBL5039808 | 0.78 | GAA (0.56) | SMN1; SMN2NAAAHDAC1NAMPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |