Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NAAA | Q02083 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039921 | 0.92 | SMN1; SMN2 (0.56) | SMN1; SMN2NAAASIGMAR1TMEM97L3MBTL1 | |
| SCHEMBL5039808 | 0.88 | GAA (0.56) | SMN1; SMN2NAAASIGMAR1 | |
| SCHEMBL5041082 | 0.88 | NAAA (0.60) | SMN1; SMN2NAAASIGMAR1TMEM97CNR2 | |
| SCHEMBL1858834 | 0.87 | NAAA (0.52) | SMN1; SMN2NAAASIGMAR1TMEM97CNR2 | |
| SCHEMBL5039801 | 0.87 | SIGMAR1 (0.53) | SMN1; SMN2NAAASIGMAR1TMEM97HDAC3 | |
| SCHEMBL5045478 | 0.86 | NAAA (0.54) | SMN1; SMN2NAAASIGMAR1TMEM97 | |
| SCHEMBL5044104 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2NAAASIGMAR1TMEM97L3MBTL1 | |
| SCHEMBL28752189 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2NAAACNR2L3MBTL1HDAC3 | |
| SCHEMBL5044747 | 0.84 | HDAC2 (0.52) | SMN1; SMN2NAAAHDAC8 | |
| SCHEMBL5047548 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2NAAASIGMAR1TMEM97L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |