Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023308 | 0.92 | MAPK14 (0.51) | EPHX2NR1H4HPGDPPARAPPARG | |
| SCHEMBL5044609 | 0.89 | EPHX2 (0.52) | EPHX2NR1H4ALDH1A1HPGDKDM4E | |
| SCHEMBL6022102 | 0.87 | LSS (0.47) | EPHX2PPARAPPARGS1PR2S1PR4 | |
| SCHEMBL1856089 | 0.87 | EPHX2 (0.46) | EPHX2NR1H4ALDH1A1HPGDKDM4E | |
| SCHEMBL5044895 | 0.86 | EPHX2 (0.48) | EPHX2NR1H4ALDH1A1HPGDKDM4E | |
| SCHEMBL5044857 | 0.85 | MAPK14 (0.51) | EPHX2ALDH1A1HPGDCYP3A4PPARA | |
| SCHEMBL5044608 | 0.81 | EPHX2 (0.49) | EPHX2NR1H4ALDH1A1HPGDKDM4E | |
| SCHEMBL5044189 | 0.80 | FFAR1 (0.47) | ALDH1A1HPGDKDM4ESMN1; SMN2HDAC1 | |
| SCHEMBL1861388 | 0.80 | MAPK14 (0.47) | EPHX2NR1H4ALDH1A1HPGDKDM4E | |
| SCHEMBL1853096 | 0.80 | ALDH1A1 (0.46) | EPHX2NR1H4ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |