Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 13/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATP4A | P20648 | 2/20 | 0.41 |
| ▸ | ATP4B | P51164 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4322789 | 0.79 | TP53 (0.51) | TP53LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5047430 | 0.78 | HDAC8 (0.53) | — | |
| SCHEMBL5045025 | 0.78 | TP53 (0.47) | TP53LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6804927 | 0.76 | TP53 (0.46) | TP53LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4320499 | 0.75 | TP53 (0.44) | TP53LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4670229 | 0.75 | TP53 (0.49) | TP53LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL1854166 | 0.75 | TP53 (0.49) | TP53LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5047553 | 0.74 | TAAR1 (0.39) | — | |
| SCHEMBL5046020 | 0.72 | PPARG (0.53) | — | |
| SCHEMBL4320498 | 0.72 | TP53 (0.47) | TP53LMNAMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |