Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 13/20 | 0.46 |
| ▸ | LMNA | P02545 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ATP4A | P20648 | 2/20 | 0.42 |
| ▸ | ATP4B | P51164 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045025 | 0.83 | TP53 (0.47) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL4322789 | 0.83 | TP53 (0.51) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL5045018 | 0.76 | TP53 (0.45) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL4670229 | 0.76 | TP53 (0.49) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL1854166 | 0.76 | TP53 (0.49) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL4320498 | 0.73 | TP53 (0.47) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL4907133 | 0.73 | LMNA (0.56) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL4903824 | 0.73 | LMNA (0.53) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL27912402 | 0.73 | LMNA (0.55) | TP53LMNAPOLBMAPTKDM4E | |
| SCHEMBL2056125 | 0.73 | TP53 (0.55) | TP53LMNAPOLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |