SCHEMBL5045089

SCHEMBL5045089

CCOC(=O)C(=Cc1ccc(-c2nc3ccccc3o2)cc1)C(=O)OCC

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.57
KMT2A Q03164 6/20 0.57
MAPT P10636 8/20 0.53
NPC1 O15118 5/20 0.53
RAB9A P51151 5/20 0.53
KDM4E B2RXH2 5/20 0.53
ALDH1A1 P00352 4/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
HPGD P15428 3/20 0.53
HSD17B10 Q99714 2/20 0.53
TDP1 Q9NUW8 1/20 0.51
LMNA P02545 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
S1PR4 O95977 1/20 0.50
S1PR1 P21453 1/20 0.50
MAPK1 P28482 1/20 0.50
NR1H4 Q96RI1 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14095573 0.93 MAPT (0.49) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL14095576 0.93 MAPT (0.49) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL5042031 0.89 MAPT (0.51) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL5045843 0.85 ESR1 (0.55) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL5045097 0.80 KDM4E (0.47) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL5044883 0.79 TLR7 (0.48) MEN1KMT2AMAPTSMN1; SMN2LMNA
SCHEMBL14192985 0.79 MAPT (0.50) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL11328161 0.78 MAPT (0.65) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL19533679 0.78 MAPT (0.61) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL5045336 0.78 ALDH1A1 (0.43) MEN1KMT2AMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7414138-B2 Benzoxazole and benzodiazole UV-A sunscreens DSM IP ASSETS B.V. (NL) 2008-08-19 US claimed
US-20050260144-A1 Benzoxazole and benzodiazole uv-a sunscreens DSM IP ASSETS B.V. (NL) 2005-11-24 US claimed
EP-1515694-A1 BENZOXAZOLE AND BENZODIAZOLE UV-A SUNSCREENS DSM IP Assets B.V. (NL) 2005-03-23 EP claimed
WO-2004000256-A1 BENZOXAZOLE AND BENZODIAZOLE UV-A SUNSCREENS DSM IP ASSETS B.V. (NL) 2003-12-31 WO claimed
EP-1953180-B1 OXYGEN-ABSORBING RESIN, OXYGEN-ABSORBING RESIN COMPOSITION AND OXYGEN-ABSORBING CONTAINER TOYO SEIKAN KAISHA LTD (JP) 2016-04-06 EP disclosed
US-7414138-B2 Benzoxazole and benzodiazole UV-A sunscreens DSM IP ASSETS B.V. (NL) 2008-08-19 US disclosed
US-7414138-B2 Benzoxazole and benzodiazole UV-A sunscreens DSM IP ASSETS B.V. (NL) 2008-08-19 US disclosed
EP-1953180-A1 OXYGEN-ABSORBING RESIN, OXYGEN-ABSORBING RESIN COMPOSITION AND OXYGEN-ABSORBING CONTAINER TOYO SEIKAN KAISYA, LTD. (JP) 2008-08-06 EP disclosed
US-20050260144-A1 Benzoxazole and benzodiazole uv-a sunscreens DSM IP ASSETS B.V. (NL) 2005-11-24 US disclosed
EP-1515694-A1 BENZOXAZOLE AND BENZODIAZOLE UV-A SUNSCREENS DSM IP Assets B.V. (NL) 2005-03-23 EP disclosed
WO-2004000256-A1 BENZOXAZOLE AND BENZODIAZOLE UV-A SUNSCREENS DSM IP ASSETS B.V. (NL) 2003-12-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050260144-A1 Benzoxazole and benzodiazole uv-a sunscreens SUN2, CYP27B1, ERCC4 MEN1 3791/4885KMT2A 2894/4885MAPT 543/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.