Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.44 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095608 | 0.88 | ALDH1A1 (0.53) | ALDH1A1TSHRSMN1; SMN2CCNE1CDK2 | |
| SCHEMBL10233485 | 0.86 | SCD (0.44) | ALDH1A1TSHRSMN1; SMN2CCNE1CDK2 | |
| SCHEMBL8834765 | 0.86 | CCNE1 (0.52) | ALDH1A1TSHRSMN1; SMN2CCNE1CDK2 | |
| SCHEMBL1031633 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL15839429 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL28148958 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL29170444 | 0.84 | CA1 (0.47) | SMN1; SMN2CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL21222206 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TSHRSMN1; SMN2CCNE1CDK2 | |
| SCHEMBL21229046 | 0.84 | SMN1; SMN2 (0.43) | ALDH1A1TSHRSMN1; SMN2CCNE1CDK2 | |
| SCHEMBL12725091 | 0.83 | FDPS (0.49) | ALDH1A1TSHRSMN1; SMN2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407946-B2 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2008-08-05 | — | — | US | disclosed |
| US-20060058523-A1 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058523-A1 | Quinazoline compounds | NDUFS5, ABL1, NDUFS7 | ALDH1A1 1630/4885TSHR 2810/4885SMN1; SMN2 1989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.