Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 7/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497465 | 0.88 | CCR1 (0.67) | CCR1MEN1KMT2ATRPA1 | |
| SCHEMBL4497464 | 0.88 | CCR1 (0.67) | CCR1MEN1KMT2ATRPA1 | |
| SCHEMBL3943101 | 0.78 | CCR1 (0.59) | CCR1DRD2 | |
| SCHEMBL3943882 | 0.77 | DRD2 (0.59) | CCR1DRD2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5050629 | 0.76 | CCR1 (0.49) | CCR1DRD2MEN1KMT2AHTT | |
| SCHEMBL4504830 | 0.74 | CCR1 (0.61) | CCR1MEN1KMT2AMMP14ADAMTS5 | |
| SCHEMBL4504825 | 0.74 | CCR1 (0.61) | CCR1MEN1KMT2AMMP14ADAMTS5 | |
| SCHEMBL13606430 | 0.73 | CCR1 (0.67) | CCR1 | |
| SCHEMBL4507643 | 0.73 | CCR1 (0.74) | CCR1 | |
| SCHEMBL4507638 | 0.73 | CCR1 (0.74) | CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973880-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Brystol-Myers Squibb Company (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087585-A1 | PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-02 | — | — | WO | disclosed |