Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.59 |
| ▸ | CCR1 | P32246 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2159538 | 0.88 | CCR1 (0.68) | DRD2CCR1 | |
| SCHEMBL2159540 | 0.88 | CCR1 (0.68) | DRD2CCR1 | |
| SCHEMBL3943101 | 0.83 | CCR1 (0.59) | DRD2CCR1 | |
| SCHEMBL3950049 | 0.81 | CCR1 (0.81) | CCR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3941668 | 0.80 | CCR1 (0.78) | CCR1 | |
| SCHEMBL557597 | 0.79 | DRD2 (0.61) | DRD2CCR1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3947720 | 0.78 | MEN1 (0.61) | CCR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5045757 | 0.77 | CCR1 (0.54) | DRD2CCR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3941475 | 0.76 | DRD2 (0.61) | DRD2CCR1 | |
| SCHEMBL3940785 | 0.76 | CCR1 (0.56) | CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049486-A2 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007092681-A2 | PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |