Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372594 | 0.85 | GPR119 (0.66) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5050653 | 0.82 | GPR119 (0.39) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389167 | 0.81 | GPR119 (0.84) | GPR119CYP2C9KCNH2 | |
| SCHEMBL16384785 | 0.74 | GPR119 (0.51) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5140723 | 0.74 | GPR119 (0.51) | GPR119CYP2C9KCNH2 | |
| SCHEMBL14357664 | 0.74 | GPR119 (0.55) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5824241 | 0.73 | EGFR (0.47) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5140547 | 0.70 | GPR119 (0.69) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5052027 | 0.70 | GPR119 (0.38) | GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL6065686 | 0.69 | GPR119 (0.46) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |