Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | SGK1 | O00141 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390005 | 0.83 | GPR119 (0.61) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3257673 | 0.82 | GPR119 (0.48) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5140723 | 0.74 | GPR119 (0.51) | GPR119CYP2C9KCNH2MKNK2 | |
| SCHEMBL5045857 | 0.72 | GPR119 (0.51) | GPR119CYP2C9EGFR | |
| SCHEMBL5046463 | 0.70 | GPR119 (0.55) | GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL391409 | 0.70 | GPR119 (0.67) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3139864 | 0.69 | GPR119 (0.75) | GPR119CYP2C9KCNH2 | |
| SCHEMBL6065460 | 0.69 | GPR119 (0.50) | GPR119CYP2C9KCNH2EGFRCYP11B1 | |
| SCHEMBL14357664 | 0.69 | GPR119 (0.55) | GPR119CYP2C9KCNH2EGFRMKNK2 | |
| SCHEMBL1897946 | 0.69 | GPR119 (0.56) | GPR119CYP2C9KCNH2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |