Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.35 |
| ▸ | FLT1 | P17948 | 4/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.35 |
| ▸ | FLT4 | P35916 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.33 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 2/20 | 0.30 |
| ▸ | LCT | P09848 | 2/20 | 0.30 |
| ▸ | UGCG | Q16739 | 2/20 | 0.30 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050508 | 0.79 | DPP4 (0.39) | DPP4FGFR1FLT1FGFR2FGFR4 | |
| SCHEMBL4592205 | 0.77 | CYP19A1 (0.44) | CYP19A1ESR1ESR2 | |
| SCHEMBL9834056 | 0.71 | CYP19A1 (0.41) | DPP4FGFR1FLT1FGFR2FGFR4 | |
| SCHEMBL28686954 | 0.67 | DPP4 (0.38) | DPP4FGFR1FLT1FGFR2FGFR4 | |
| SCHEMBL10065552 | 0.67 | TSHR (0.39) | DPP4CYP19A1 | |
| SCHEMBL28761316 | 0.67 | PSEN1 (0.37) | DPP4CYP19A1CCR1CCR2CCR4 | |
| SCHEMBL4599537 | 0.67 | TYR (0.37) | DPP4KDRPDGFRBCYP19A1ESR1 | |
| SCHEMBL5046643 | 0.66 | ATP4A (0.52) | CYP19A1NPC1 | |
| SCHEMBL29447736 | 0.66 | DPP4 (0.37) | DPP4FGFR1FLT1FGFR2FGFR4 | |
| SCHEMBL10976644 | 0.65 | PDGFRB (0.35) | KDRPDGFRBCYP19A1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432291-B2 | Ether derivatives | HOFFMAN-LA ROCHE INC. (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1727815-B1 | ETHER DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2007-06-27 | — | — | EP | disclosed |
| CN-1930154-A | Ether derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2007-03-14 | — | — | CN | disclosed |
| EP-1727815-A1 | ETHER DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005090338-A1 | ETHER DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-29 | — | — | WO | disclosed |
| US-20050209290-A1 | Novel ether derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209290-A1 | Novel ether derivatives | CYP2E1, CYP11B1, CYP11B2 | DPP4 1749/4885FGFR1 2092/4885FLT1 3782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.