Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.32 |
| ▸ | FLT1 | P17948 | 4/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.32 |
| ▸ | FLT4 | P35916 | 4/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ATP4A | P20648 | 1/20 | 0.31 |
| ▸ | ATP4B | P51164 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049275 | 0.87 | GAA (0.37) | FGFR1MEN1LMNAMAPTKMT2A | |
| SCHEMBL4592008 | 0.82 | ALDH1A1 (0.38) | EGFRLMNAMAPTSMN1; SMN2ATP4A | |
| SCHEMBL5046467 | 0.79 | DPP4 (0.42) | DPP4FGFR1FLT1FGFR2FGFR4 | |
| SCHEMBL5046644 | 0.71 | ERBB2 (0.36) | ATP4AATP4B | |
| SCHEMBL5046147 | 0.71 | ERBB2 (0.56) | MAPT | |
| SCHEMBL5046647 | 0.71 | ERBB2 (0.36) | ATP4AATP4B | |
| SCHEMBL5046142 | 0.71 | ERBB2 (0.56) | MAPT | |
| SCHEMBL4607300 | 0.71 | MAOA (0.34) | FGFR1MEN1LMNAMAPTKMT2A | |
| SCHEMBL4606288 | 0.69 | MAOA (0.33) | FGFR1MAOA | |
| SCHEMBL5047814 | 0.67 | MAPT (0.46) | HTR2AKAT6AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432291-B2 | Ether derivatives | HOFFMAN-LA ROCHE INC. (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1727815-B1 | ETHER DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2007-06-27 | — | — | EP | disclosed |
| CN-1930154-A | Ether derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2007-03-14 | — | — | CN | disclosed |
| EP-1727815-A1 | ETHER DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005090338-A1 | ETHER DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-29 | — | — | WO | disclosed |
| US-20050209290-A1 | Novel ether derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209290-A1 | Novel ether derivatives | CYP2E1, CYP11B1, CYP11B2 | DPP4 1749/4885HTR2A 3596/4885FGFR1 2092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.