Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046797 | 0.92 | MAOB (0.40) | ORAI1OPRD1OPRK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5046577 | 0.87 | KIF11 (0.40) | METKMT2A | |
| SCHEMBL5046596 | 0.83 | MET (0.45) | GRM5ALDH1A1HPGDRAB9AMAOB | |
| SCHEMBL5050486 | 0.80 | MET (0.51) | ORAI1OPRD1OPRK1ALDH1A1MET | |
| SCHEMBL17004388 | 0.76 | GRM5 (0.39) | GRM5SMN1; SMN2ALDH1A1HPGDRAB9A | |
| SCHEMBL17004377 | 0.76 | MET (0.44) | GRM5SMN1; SMN2ALDH1A1RAB9AHCRTR1 | |
| SCHEMBL17004402 | 0.76 | ORAI1 (0.49) | GRM5ORAI1OPRK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5050458 | 0.75 | MET (0.46) | MAOBMET | |
| SCHEMBL14484340 | 0.74 | MAOB (0.60) | SMN1; SMN2ALDH1A1HPGDRAB9AMAOB | |
| SCHEMBL980138 | 0.73 | HCRTR1 (0.35) | BCL2A1SMN1; SMN2ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-10-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MET, FLT3, ERBB3 | GRM5 2622/4885ORAI1 4824/4885OPRD1 1946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.