Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043264 | 0.89 | SMN1; SMN2 (0.49) | L3MBTL1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5050279 | 0.88 | KDM4E (0.46) | SMN1; SMN2MEN1KMT2AHDAC1KDM4E | |
| SCHEMBL5049381 | 0.87 | ROCK2 (0.53) | SMN1; SMN2MEN1KMT2AHDAC1KDM4E | |
| SCHEMBL5046403 | 0.83 | KDM4E (0.51) | SMN1; SMN2ALDH1A1HDAC1KDM4EMAPK1 | |
| SCHEMBL5048180 | 0.83 | ADRB2 (0.44) | SMN1; SMN2MEN1KMT2ABCHEHDAC1 | |
| SCHEMBL5048113 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2ABCHEHDAC1 | |
| SCHEMBL5049384 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ABCHEHDAC1 | |
| SCHEMBL5049396 | 0.80 | CA12 (0.55) | PTPN1 | |
| SCHEMBL15876016 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2ABCHEHDAC1 | |
| SCHEMBL5046821 | 0.78 | PTGER2 (0.48) | SMN1; SMN2HDAC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |