Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | PRKX | P51817 | 2/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046403 | 0.90 | KDM4E (0.51) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5048113 | 0.90 | SMN1; SMN2 (0.45) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5043264 | 0.89 | SMN1; SMN2 (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5050279 | 0.87 | KDM4E (0.46) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5046663 | 0.87 | L3MBTL1 (0.45) | SMN1; SMN2MEN1MAPK1HTTKMT2A | |
| SCHEMBL5048180 | 0.86 | ADRB2 (0.44) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5049384 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2AKDM4EHDAC1 | |
| SCHEMBL5046565 | 0.82 | MAPT (0.46) | CYP3A4CYP2D6SMN1; SMN2MEN1MAPK1 | |
| SCHEMBL15876016 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AHDAC1 | |
| SCHEMBL5046821 | 0.81 | PTGER2 (0.48) | SMN1; SMN2KDM4EHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |