Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050458 | 0.89 | MET (0.46) | METEPHX2HSP90AA1SRCMAPK14 | |
| SCHEMBL5046596 | 0.88 | MET (0.45) | METEPHX2HSP90AA1SRCALDH1A1 | |
| SCHEMBL5046577 | 0.83 | KIF11 (0.40) | METKIF11 | |
| SCHEMBL981265 | 0.75 | KIF11 (0.45) | METKIF11EPHX2MAPK14PCSK9 | |
| SCHEMBL17004383 | 0.75 | MET (0.49) | METKIF11ALDH1A1 | |
| SCHEMBL5046797 | 0.71 | MAOB (0.40) | METALDH1A1 | |
| SCHEMBL5046612 | 0.71 | GRM5 (0.37) | METALDH1A1 | |
| SCHEMBL12922939 | 0.69 | MET (0.72) | METEPHX2 | |
| SCHEMBL981952 | 0.69 | PARP1 (0.34) | METKIF11 | |
| SCHEMBL981914 | 0.68 | POLB (0.42) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-10-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MET, FLT3, ERBB3 | MET 1/4885KIF11 3068/4885EPHX2 3630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.