Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | CNKSR1 | Q969H4 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1653068 | 0.81 | MEN1 (0.46) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL3253926 | 0.73 | BRD4 (0.54) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL1653275 | 0.73 | HIF1A (0.51) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL5046915 | 0.73 | ALDH1A1 (0.49) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL7570349 | 0.72 | ALDH1A1 (0.60) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL1652707 | 0.72 | CNKSR1 (0.47) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL1653221 | 0.72 | MEN1 (0.49) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL2354908 | 0.72 | MEN1 (0.53) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL1653185 | 0.72 | ALDH1A1 (0.44) | MAPTMEN1KMT2ANPSR1HIF1A | |
| SCHEMBL1653948 | 0.71 | ALDH1A1 (0.52) | MAPTMEN1KMT2ANPSR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1873144-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-01-02 | — | — | EP | disclosed |