Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 4/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044937 | 0.86 | F10 (0.44) | CTSLCTSBCTSSCTSKGPR139 | |
| SCHEMBL5039519 | 0.85 | UTS2R (0.48) | UTS2RMCHR1MME | |
| SCHEMBL5047059 | 0.83 | GPR139 (0.45) | CTSLCTSBCTSSCTSKGPR139 | |
| SCHEMBL6022413 | 0.81 | GAA (0.46) | GAAMAPTRAB9ANPC1SNCA | |
| SCHEMBL5047823 | 0.81 | GAA (0.46) | GAAMAPTRAB9ANPC1SNCA | |
| SCHEMBL5047048 | 0.81 | EPHX2 (0.41) | CTSLCTSBCTSSCTSKGPR139 | |
| SCHEMBL1851611 | 0.80 | GAA (0.43) | GAACTSLCTSSMAPTRAB9A | |
| SCHEMBL6022596 | 0.72 | F10 (0.49) | CTSLCTSBCTSSCTSKGPR139 | |
| SCHEMBL4312857 | 0.71 | PTGES (0.40) | CTSLCTSSMAPTRAB9ANPC1 | |
| SCHEMBL5044420 | 0.69 | GPR139 (0.46) | CTSLCTSBCTSSCTSKGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |