Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047059 | 0.88 | GPR139 (0.45) | GPR139CTSLCTSBCTSSCTSK | |
| SCHEMBL5047048 | 0.87 | EPHX2 (0.41) | GPR139CTSLCTSBCTSSCTSK | |
| SCHEMBL5048049 | 0.86 | GAA (0.39) | NPC1RAB9AGPR139CTSLCTSB | |
| SCHEMBL6022596 | 0.86 | F10 (0.49) | F10KDM4BNPC1RAB9ANAMPT | |
| SCHEMBL5047546 | 0.80 | NPC1 (0.50) | F10KDM4BNPC1RAB9ANAMPT | |
| SCHEMBL1856432 | 0.79 | F10 (0.47) | F10KDM4BNPC1RAB9ANAMPT | |
| SCHEMBL5044420 | 0.73 | GPR139 (0.46) | F10ALDH1A1GPR139CTSLCTSB | |
| SCHEMBL5047162 | 0.72 | HDAC1 (0.44) | SMN1; SMN2ALDH1A1HDAC1HDAC2 | |
| SCHEMBL5039660 | 0.72 | HDAC1 (0.44) | SMN1; SMN2ALDH1A1HDAC1HDAC2 | |
| SCHEMBL5046973 | 0.72 | UTS2R (0.47) | RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |