SCHEMBL5048148

SCHEMBL5048148

Cl[Si](Cl)(c1cccc2ccccc12)c1cccc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.48
CYP1A2 P05177 5/20 0.48
ALDH1A1 P00352 6/20 0.46
HSD17B10 Q99714 4/20 0.46
TSHR P16473 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
HPGD P15428 2/20 0.42
CYP3A4 P08684 1/20 0.42
KEAP1 Q14145 1/20 0.42
HPRT1 P00492 1/20 0.42
PAX8 Q06710 1/20 0.39
HIF1A Q16665 1/20 0.39
CYP1B1 Q16678 1/20 0.39
THRB P10828 1/20 0.39
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
NR4A1 P22736 1/20 0.37
NR4A2 P43354 1/20 0.37
NR4A3 Q92570 1/20 0.37
F12 P00748 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31643929 0.87 CYP1A2 (0.41) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL8207775 0.87 CYP1A2 (0.41) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL30190041 0.85 CYP2A6 (0.48) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL1131122 0.85 CYP2A6 (0.48) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL2932475 0.85 CYP2A6 (0.48) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL8768022 0.82 CYP2A6 (0.42) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL17966499 0.81 CYP2A6 (0.44) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL10319492 0.81 CYP2A6 (0.44) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL8216176 0.81 CYP2A6 (0.44) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL15067611 0.80 CYP2A6 (0.38) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880549-A2 CATALYST SYSTEM AND COMPONENTS EXXON CHEMICAL PATENTS INC. (US) 1998-12-02 EP claimed
WO-1997030096-A2 CATALYST SYSTEM AND COMPONENTS EXXON CHEMICAL PATENTS INC. (US) 1997-08-21 WO claimed
EP-3039080-B1 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE DUPONT TORAY SPECIALTY MATERIALS KK (JP) 2022-05-11 EP disclosed
CN-113214651-A Curable silicone composition, cured product thereof, and optical semiconductor device 杜邦东丽特殊材料株式会社 2021-08-06 CN disclosed
US-20210036245-A1 HETEROAROMATIC COMPOUNDS MERCK PATENT GMBH (DE) 2021-02-04 US disclosed
CN-107223127-B Method for producing organohalosilanes 美国陶氏有机硅公司 2020-09-11 CN disclosed
EP-3253770-B1 METHOD OF PRODUCING ORGANOHALOSILANES DOW SILICONES CORP (US) 2020-09-02 EP disclosed
EP-3253771-B1 METHOD OF PRODUCING ORGANOHALOSILANES DOW SILICONES CORP (US) 2020-08-12 EP disclosed
CN-107206355-B Method for producing organohalosilanes 美国陶氏有机硅公司 2020-07-07 CN disclosed
US-20190263841-A1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2019-08-29 US disclosed
US-10336913-B2 Curable silicone composition, cured product thereof, and optical semiconductor device DOW CORNING TORAY CO., LTD. (JP) 2019-07-02 US disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0617044-B1 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI CHEMICALS INC (JP) 1999-01-20 EP disclosed
EP-0880549-A2 CATALYST SYSTEM AND COMPONENTS EXXON CHEMICAL PATENTS INC. (US) 1998-12-02 EP disclosed
WO-1997030096-A2 CATALYST SYSTEM AND COMPONENTS EXXON CHEMICAL PATENTS INC. (US) 1997-08-21 WO disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed
US-5360921-A REACTING LITHIUM, SODIUM OR POTASSIUM SALT OF A CYCLOPENTADIENE DERIVATIVE WITH A SILICON OR GERMANIUM HALIDE COMPOUND IN THE PRESENCE OF A CYANIDE OR A THIOCYANATE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-11-01 US disclosed
EP-0617044-A2 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-09-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190263841-A1 COMPOUNDS FOR ELECTRONIC DEVICES ETV6, EED, FES CYP2A6 2210/4885CYP1A2 1050/4885ALDH1A1 636/4885
US-20210036245-A1 HETEROAROMATIC COMPOUNDS ETV6, FES, LEF1 CYP2A6 1117/4885CYP1A2 281/4885ALDH1A1 752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.