SCHEMBL8207775

SCHEMBL8207775

Cl[Si](Cl)(c1ccccc1)c1cccc2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.41
CYP2A6 P11509 4/20 0.41
ALDH1A1 P00352 7/20 0.39
HSD17B10 Q99714 5/20 0.39
TSHR P16473 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
CYP3A4 P08684 3/20 0.37
HPGD P15428 3/20 0.37
KEAP1 Q14145 1/20 0.37
NR4A1 P22736 1/20 0.36
NR4A2 P43354 1/20 0.36
NR4A3 Q92570 1/20 0.36
HPRT1 P00492 1/20 0.36
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
TP53 P04637 1/20 0.35
ALOX15 P16050 1/20 0.35
CDC25B P30305 1/20 0.35
ATM Q13315 1/20 0.35
CYP2C9 P11712 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31643929 1.00 CYP1A2 (0.41) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL15848589 0.89 HPRT1 (0.50) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL5048148 0.87 CYP2A6 (0.48) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL8768022 0.86 CYP2A6 (0.42) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL15848065 0.82 ALDH1A1 (0.37) CYP1A2ALDH1A1HSD17B10HPGDMAOA
SCHEMBL15067611 0.81 CYP2A6 (0.38) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL9302117 0.80 CYP2A6 (0.39) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL16361036 0.78 ALDH1A1 (0.42) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL8173517 0.78 ALDH1A1 (0.42) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR
SCHEMBL1131122 0.78 CYP2A6 (0.48) CYP1A2CYP2A6ALDH1A1HSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210036245-A1 HETEROAROMATIC COMPOUNDS MERCK PATENT GMBH (DE) 2021-02-04 US disclosed
US-20190263841-A1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2019-08-29 US disclosed
WO-2018087020-A1 COMPOUNDS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2018-05-17 WO disclosed
CN-106967107-A The method for producing organo-silicon compound 道康宁东丽株式会社 2017-07-21 CN disclosed
US-9260458-B2 Method of producing an organic silicon compound DOW CORNING CORPORATION (US) 2016-02-16 US disclosed
US-20150344735-A1 Curable Silicone Composition, Cured Product Thereof, And Optical Semiconductor Device DOW CORNING TORAY CO., LTD. (JP) 2015-12-03 US disclosed
US-20150344636-A1 Curable Silicone Composition, Cured Product Thereof, And Optical Semiconductor Device DOW CORNING TORAY CO., LTD. (JP) 2015-12-03 US disclosed
US-20150141689-A1 Method Of Producing An Organic Silicon Compound DOW TORAY CO., LTD. (JP) 2015-05-21 US disclosed
EP-2797855-A1 METHOD OF PRODUCING AN ORGANIC SILICON COMPOUND Dow Corning Toray Co., Ltd. (JP) 2014-11-05 EP disclosed
WO-2014104390-A2 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE DOW CORNING TORAY CO., LTD. (JP) 2014-07-03 WO disclosed
WO-2014104388-A2 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE DOW CORNING TORAY CO., LTD. (JP) 2014-07-03 WO disclosed
WO-2013100166-A1 METHOD OF PRODUCING AN ORGANIC SILICON COMPOUND DOW CORNING TORAY CO., LTD. (JP) 2013-07-04 WO disclosed
US-6025117-A USING POLYSILANE COPOLYMER OR DENDRIMER FILM PATTERN AS MASK FOR ETCHING INSULATING OR CONDUCTING LAYER ON SUBSTRATE KABUSHIKI KAISHA TOSHIBA (JP) 2000-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190263841-A1 COMPOUNDS FOR ELECTRONIC DEVICES ETV6, EED, FES CYP1A2 1050/4885CYP2A6 2210/4885ALDH1A1 636/4885
US-20210036245-A1 HETEROAROMATIC COMPOUNDS ETV6, FES, LEF1 CYP1A2 281/4885CYP2A6 1117/4885ALDH1A1 752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.