Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769180 | 0.92 | GCGR (0.46) | PTGS2ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL8001119 | 0.77 | CYP1A2 (0.47) | GSK3BKDM4EGAAMAPTLMNA | |
| SCHEMBL3816794 | 0.68 | GSK3B (0.67) | PTGS2GSK3BGSK3A | |
| SCHEMBL6111216 | 0.68 | NOTUM (0.36) | RECQLNOTUMALDH1A1KDM4EGAA | |
| SCHEMBL6704189 | 0.65 | PTGS2 (0.58) | PTGS2GSK3BRECQLALDH1A1KDM4E | |
| SCHEMBL3823878 | 0.64 | PTGS2 (0.56) | PTGS2GSK3BKDM4EGAAMAPT | |
| SCHEMBL3820693 | 0.63 | GSK3B (0.63) | PTGS2GSK3BGSK3A | |
| SCHEMBL10593567 | 0.63 | CYP2D6 (0.39) | PTGS2GSK3BRECQLNOTUMALDH1A1 | |
| SCHEMBL91966 | 0.63 | PTGS2 (0.50) | PTGS2GSK3BRECQLNOTUMALDH1A1 | |
| SCHEMBL3823556 | 0.62 | GSK3B (0.54) | PTGS2GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891074-A1 | AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS | Brystol-Myers Squibb Company (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006138682-A1 | AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-28 | — | — | WO | disclosed |
| EP-1697371-A1 | AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS | Bristol-Myers Squibb Company (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005063762-A1 | AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-14 | — | — | WO | disclosed |