Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3342656 | 0.82 | PREP (0.57) | ALDH1A1SMN1; SMN2HRH3DPP4DPP8 | |
| SCHEMBL3336958 | 0.82 | PREP (0.57) | ALDH1A1SMN1; SMN2HRH3DPP4DPP8 | |
| SCHEMBL25186706 | 0.82 | PREP (0.57) | ALDH1A1SMN1; SMN2HRH3DPP4DPP8 | |
| SCHEMBL22370828 | 0.81 | MGLL (0.47) | ALDH1A1KDM4E | |
| SCHEMBL22370789 | 0.81 | MGLL (0.47) | ALDH1A1KDM4E | |
| SCHEMBL5566878 | 0.80 | CTSL (0.66) | MCHR2MCHR1CTSLCTSBCTSK | |
| SCHEMBL20522842 | 0.79 | FKBP1A (0.54) | ALDH1A1SMN1; SMN2HRH3HCRTR1HCRTR2 | |
| SCHEMBL28978206 | 0.79 | FKBP1A (0.54) | ALDH1A1SMN1; SMN2HRH3HCRTR1HCRTR2 | |
| SCHEMBL25174182 | 0.79 | FKBP1A (0.54) | ALDH1A1SMN1; SMN2HRH3HCRTR1HCRTR2 | |
| SCHEMBL5048503 | 0.78 | FFAR1 (0.52) | ALDH1A1RAB9AHRH3KDM4EFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |