Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.38 |
| ▸ | ATP4B | P51164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039689 | 0.95 | MAPT (0.43) | EIF4EMAPTTP53SMN1; SMN2CYP3A4 | |
| SCHEMBL5044045 | 0.93 | THRB (0.45) | EIF4EMAPTTP53SMN1; SMN2CYP3A4 | |
| SCHEMBL5046059 | 0.91 | EIF4E (0.46) | EIF4EMAPTTP53CYP3A4CYP2C9 | |
| SCHEMBL5049186 | 0.91 | NPC1 (0.41) | EIF4EMAPTTP53SMN1; SMN2GAA | |
| SCHEMBL5046039 | 0.89 | CYP3A4 (0.41) | MAPTTP53SMN1; SMN2GAACYP3A4 | |
| SCHEMBL5039553 | 0.88 | KLKB1 (0.48) | EIF4EMAPTTP53SMN1; SMN2KLKB1 | |
| SCHEMBL5046060 | 0.87 | KLKB1 (0.43) | EIF4EMAPTTP53SMN1; SMN2KLKB1 | |
| SCHEMBL5048696 | 0.82 | CDC25A (0.43) | MAPTTP53SMN1; SMN2KLKB1MGLL | |
| SCHEMBL5046032 | 0.82 | KLKB1 (0.53) | EIF4EMAPTTP53SMN1; SMN2GAA | |
| SCHEMBL5048635 | 0.81 | MAPT (0.50) | EIF4EMAPTTP53SMN1; SMN2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |