Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | PTGFR | P43088 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046700 | 0.94 | LMNA (0.61) | LMNATP53L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL5045721 | 0.85 | LMNA (0.51) | LMNATP53PTGFRALDH1A1TACR3 | |
| SCHEMBL5139952 | 0.83 | LMNA (0.61) | LMNATP53L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL5042680 | 0.82 | LMNA (0.47) | LMNATP53MAPTALDH1A1TACR3 | |
| SCHEMBL5045993 | 0.80 | LMNA (0.66) | LMNATP53PTGFRL3MBTL1RAB9A | |
| SCHEMBL5045806 | 0.80 | LMNA (0.66) | LMNATP53L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL3326488 | 0.80 | PDE10A (0.62) | LMNAKMT2APDE10A | |
| SCHEMBL4667070 | 0.80 | LMNA (0.74) | LMNATP53PTGFRMAPTMEN1 | |
| SCHEMBL4667071 | 0.79 | LMNA (0.71) | LMNATP53PTGFRMAPTMEN1 | |
| SCHEMBL5048810 | 0.79 | LMNA (0.71) | LMNATP53PTGFRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137155-A1 | QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | AstraZeneca AB (SE) | 2009-12-30 | — | — | EP | claimed |
| WO-2008115140-A1 | QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | WO | claimed |