Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.45 |
| ▸ | PPARG | P37231 | 9/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 6/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MTTP | P55157 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6022101 | 0.85 | PPARG (0.46) | PPARAPPARGEPHX2PLK1PPARD | |
| SCHEMBL5045752 | 0.85 | EPHX2 (0.42) | PPARAPPARGEPHX2PPARDAKR1C3 | |
| SCHEMBL5047489 | 0.82 | PPARG (0.42) | PPARAPPARGEPHX2RORCTRPV1 | |
| SCHEMBL6022102 | 0.81 | LSS (0.47) | PPARAPPARGEPHX2PLK1PPARD | |
| SCHEMBL5048687 | 0.81 | EPHX2 (0.48) | PPARAPPARGEPHX2PPARDAKR1C3 | |
| SCHEMBL4978882 | 0.80 | PLK1 (0.47) | PPARAPLK1 | |
| SCHEMBL4317777 | 0.79 | LSS (0.49) | PPARAPPARGEPHX2PLK1PPARD | |
| SCHEMBL1852984 | 0.77 | MLYCD (0.51) | PPARAPPARGEPHX2PLK1PPARD | |
| SCHEMBL5047681 | 0.76 | DDR1 (0.43) | PPARAPPARGEPHX2PPARDTRPV1 | |
| SCHEMBL4966603 | 0.76 | PLK1 (0.43) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |