Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047681 | 0.92 | DDR1 (0.43) | EPHX2PPARAPPARGMAPK14GPR139 | |
| SCHEMBL6022121 | 0.88 | GPR139 (0.43) | MAPK14GPR139DDR1HPGDTRPV1 | |
| SCHEMBL6023307 | 0.87 | HTR2C (0.44) | EPHX2PPARAPPARGMAPK14GPR139 | |
| SCHEMBL5047489 | 0.87 | PPARG (0.42) | EPHX2PPARAPPARGKDM4EALDH1A1 | |
| SCHEMBL5049019 | 0.85 | PPARA (0.45) | EPHX2PPARAPPARGMAPK14AKR1C3 | |
| SCHEMBL5048687 | 0.84 | EPHX2 (0.48) | EPHX2PPARAPPARGMAPK14DDR1 | |
| SCHEMBL6023308 | 0.81 | MAPK14 (0.51) | EPHX2PPARAPPARGMAPK14DDR1 | |
| SCHEMBL5044895 | 0.80 | EPHX2 (0.48) | EPHX2PPARAPPARGHTR2CAKR1C3 | |
| SCHEMBL1861388 | 0.80 | MAPK14 (0.47) | EPHX2PPARAPPARGMAPK14DDR1 | |
| SCHEMBL5048757 | 0.79 | PPARG (0.44) | EPHX2PPARAPPARGKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |