Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | PPARA | Q07869 | 7/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 4/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044895 | 0.89 | EPHX2 (0.48) | PPARGPPARAEPHX2PPARDTRPV1 | |
| SCHEMBL5049019 | 0.85 | PPARA (0.45) | PPARGPPARAEPHX2PLK1LSS | |
| SCHEMBL6022102 | 0.85 | LSS (0.47) | PPARGPPARAEPHX2PLK1LSS | |
| SCHEMBL6023307 | 0.83 | HTR2C (0.44) | PPARGPPARAEPHX2TRPV1MAPK14 | |
| SCHEMBL4317777 | 0.79 | LSS (0.49) | PPARGPPARAEPHX2PLK1LSS | |
| SCHEMBL6023237 | 0.78 | EPHX2 (0.49) | PPARGPPARAEPHX2PPARDTRPV1 | |
| SCHEMBL5048870 | 0.75 | MLYCD (0.52) | PPARGPPARAPPARDHDAC1 | |
| SCHEMBL5044913 | 0.74 | HTR2A (0.43) | PLK1TRPV1HDAC1MAPK14 | |
| SCHEMBL5046020 | 0.74 | PPARG (0.53) | PPARGPPARAEPHX2PLK1LSS | |
| SCHEMBL5039489 | 0.74 | MLYCD (0.50) | PPARGPPARAEPHX2LSSPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | disclosed |