Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059035 | 0.70 | ALDH1A1 (0.45) | POLBPTGS2KDM4EALDH1A1LMNA | |
| Toluene SCHEMBL2212138 | 0.70 | POLB (0.42) | POLBHCAR2HCAR3DAOPTGS2 | |
| SCHEMBL16746780 | 0.69 | KMT2A (0.41) | POLBDAOKDM4EALDH1A1CYP1A2 | |
| SCHEMBL926966 | 0.67 | POLB (0.35) | POLBPTGS2PTGS1MAPTCXCR1 | |
| SCHEMBL10957480 | 0.65 | POLB (0.40) | POLBPTGS2PTGS1MAPTCXCR1 | |
| SCHEMBL4662149 | 0.65 | PTGS2 (0.39) | POLBHCAR3PTGS2PTGS1MAPT | |
| SCHEMBL12270026 | 0.64 | — | — | |
| SCHEMBL1565803 | 0.64 | HSD17B10 (0.46) | MAPTSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL909421 | 0.64 | HCAR2 (0.46) | POLBHCAR2HCAR3DAOPTGS2 | |
| SCHEMBL7797424 | 0.63 | XIAP (0.46) | POLBPTGS2PTGS1MAPTCXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402585-B2 | Substituted quinazoline derivatives as inhibitors of aurora kinases | ASTRAZENECA AB (SE) | 2008-07-22 | — | — | US | disclosed |
| US-20050070561-A1 | Substituted quinazoline derivatives as inhibitors of aurora kinases | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070561-A1 | Substituted quinazoline derivatives as inhibitors of aurora kinases | AURKC, AURKA, AURKB | POLB 1003/4885HCAR2 2826/4885HCAR3 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.