Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049110 | 0.70 | POLB (0.38) | POLBPTGS2PTGS1MAPTCXCR1 | |
| SCHEMBL588772 | 0.69 | LMNA (0.44) | POLBKDM4EALDH1A1LMNACYP3A4 | |
| Toluene SCHEMBL27819683 | 0.68 | LMNA (0.58) | PTGS2MAPTSMN1; SMN2ALDH1A1LMNA | |
| Toluene SCHEMBL27527983 | 0.68 | LMNA (0.58) | PTGS2MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4059035 | 0.67 | ALDH1A1 (0.45) | POLBPTGS2KDM4EALDH1A1LMNA | |
| Toluene SCHEMBL27517251 | 0.66 | LMNA (0.55) | PTGS2MAPTSMN1; SMN2ALDH1A1LMNA | |
| Toluene SCHEMBL8908638 | 0.66 | LMNA (0.55) | PTGS2MAPTSMN1; SMN2ALDH1A1LMNA | |
| Toluene SCHEMBL27885366 | 0.66 | LMNA (0.55) | PTGS2MAPTSMN1; SMN2ALDH1A1LMNA | |
| Toluene SCHEMBL25341486 | 0.65 | LMNA (0.52) | PTGS2SMN1; SMN2ALDH1A1LMNAMAPK1 | |
| Toluene SCHEMBL18837396 | 0.65 | LMNA (0.52) | PTGS2MAPTSMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342203-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-07-13 | — | — | EP | disclosed |