Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 9/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2621733 | 0.80 | EGFR (0.45) | ATMHRH3MCHR1PDPK1KDM4E | |
| SCHEMBL4586485 | 0.72 | TGFBR1 (0.39) | KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2621735 | 0.72 | ATM (0.40) | ATMPDPK1 | |
| SCHEMBL4586234 | 0.69 | ALDH1A1 (0.47) | — | |
| SCHEMBL12392176 | 0.68 | MCHR1 (0.41) | ATMHRH3MCHR1PDPK1 | |
| SCHEMBL4586097 | 0.67 | PDE10A (0.42) | MAPT | |
| SCHEMBL12806229 | 0.67 | ALDH1A1 (0.44) | HRH3KDM4EMAPT | |
| SCHEMBL3274768 | 0.64 | NPC1 (0.45) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15150330 | 0.63 | ALDH1A1 (0.44) | ATMNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL16289900 | 0.63 | CYP1A2 (0.52) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | ATM 2491/4885HRH3 1544/4885MCHR1 3324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.