Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043226 | 0.87 | PIK3CD (0.40) | S1PR1RXFP1PIK3CDPARP14CRHR1 | |
| SCHEMBL18265670 | 0.82 | PIK3CD (0.37) | S1PR1RXFP1PIK3CDPARP14CRHR1 | |
| SCHEMBL5042709 | 0.79 | PARP14 (0.38) | RXFP1PIK3CDPARP14CRHR1 | |
| SCHEMBL15702914 | 0.77 | PIK3CD (0.38) | S1PR1RXFP1PIK3CDPARP14CRHR1 | |
| SCHEMBL14472768 | 0.76 | SCN2A (0.45) | S1PR1RXFP1PIK3CDDRD4DRD3 | |
| SCHEMBL5046472 | 0.76 | DRD4 (0.43) | RXFP1PIK3CDDRD4DRD3L3MBTL1 | |
| SCHEMBL19189681 | 0.74 | ALDH1A1 (0.35) | S1PR1PIK3CD | |
| SCHEMBL14472797 | 0.74 | S1PR1 (0.35) | S1PR1RXFP1PIK3CDL3MBTL1 | |
| SCHEMBL4509933 | 0.73 | CRHR1 (0.45) | MEN1KMT2ACRHR1 | |
| SCHEMBL14602966 | 0.73 | TACR1 (0.36) | S1PR1PIK3CDCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981342-B1 | SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | REDDYS LAB LTD DR (IN) | 2016-11-30 | — | — | EP | disclosed |
| EP-1981342-A1 | SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | Reddy US Therapeutics, Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007075194-A1 | SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | REDDY US THERAPEUTICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075194-A1 | SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | REDDY US THERAPEUTICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |