Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054678 | 0.87 | RBP4 (0.40) | RBP4CNR2TRPA1TRPV1KCNH2 | |
| SCHEMBL5050040 | 0.86 | MALT1 (0.46) | TRPA1TRPV1KCNH2TRPM8MALT1 | |
| SCHEMBL5048772 | 0.85 | P2RY12 (0.41) | RBP4TRPA1PHGDHTRPV1KCNH2 | |
| SCHEMBL5054681 | 0.84 | TRPV1 (0.58) | CNR2TRPA1TRPV1KCNH2TRPM8 | |
| SCHEMBL5052836 | 0.82 | TRPA1 (0.43) | TRPA1TRPV1KCNH2TRPM8MALT1 | |
| SCHEMBL5051053 | 0.82 | TRPA1 (0.51) | TRPA1TRPV1KCNH2TRPM8 | |
| SCHEMBL5054571 | 0.81 | TRPA1 (0.40) | RBP4CNR2TRPA1TRPV1KCNH2 | |
| SCHEMBL5052859 | 0.80 | TSHR (0.44) | TRPA1TRPV1MALT1 | |
| SCHEMBL5050214 | 0.79 | RBP4 (0.47) | RBP4TRPA1TRPV1KCNH2TRPM8 | |
| SCHEMBL1457170 | 0.79 | RBP4 (0.41) | RBP4CNR2TRPA1PHGDHTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893620-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006122769-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |