Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054571 | 0.88 | TRPA1 (0.40) | CHRM4TRPA1TRPV1 | |
| SCHEMBL5050040 | 0.87 | MALT1 (0.46) | TRPA1TRPV1MALT1 | |
| SCHEMBL5048772 | 0.86 | P2RY12 (0.41) | P2RY12TRPA1TRPV1 | |
| SCHEMBL5054678 | 0.83 | RBP4 (0.40) | TRPA1TRPV1 | |
| SCHEMBL5052836 | 0.83 | TRPA1 (0.43) | TRPA1TRPV1MALT1 | |
| SCHEMBL5050042 | 0.80 | P2RX7 (0.41) | CHRM4TRPA1TRPV1MALT1 | |
| SCHEMBL5051053 | 0.80 | TRPA1 (0.51) | TRPA1TRPV1 | |
| SCHEMBL5054681 | 0.80 | TRPV1 (0.58) | TRPA1TRPV1 | |
| SCHEMBL5050232 | 0.80 | RBP4 (0.41) | TRPA1TRPV1MALT1 | |
| SCHEMBL1456944 | 0.79 | CHRM4 (0.45) | TSHRHSD17B10CHRM4P2RY12TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893620-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006122769-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |