Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 5/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | CCR7 | P32248 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046784 | 0.82 | HSD17B10 (0.45) | GPR84HSD17B10GAAHTTTHRB | |
| SCHEMBL5046796 | 0.78 | CXCR4 (0.47) | GPR84KCNH2HSD17B10GAAKDM4E | |
| SCHEMBL6023033 | 0.74 | HSD17B10 (0.44) | GPR84HSD17B10GAAHTTMEN1 | |
| SCHEMBL6023036 | 0.73 | HSD17B10 (0.39) | GPR84HSD17B10GAAKDM4EHTT | |
| SCHEMBL5049122 | 0.72 | GPR84 (0.44) | GPR84HSD17B10GAAKDM4EHTT | |
| SCHEMBL6022136 | 0.69 | ALOX15 (0.51) | GPR84HSD17B10GAAKDM4EHTT | |
| SCHEMBL7021631 | 0.68 | GPR84 (0.47) | GPR84HSD17B10GAAKDM4EHTT | |
| SCHEMBL7022821 | 0.68 | GPR84 (0.47) | GPR84HSD17B10GAAKDM4EHTT | |
| SCHEMBL5045978 | 0.65 | GPR84 (0.50) | GPR84HSD17B10GAAKDM4EHTT | |
| SCHEMBL11334284 | 0.65 | SMN1; SMN2 (0.51) | GPR84HSD17B10GAAKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351700-B2 | Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors | HOFFMANN-LA ROCHE INC. (US) | 2008-04-01 | — | — | US | claimed |