Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14416 | 0.92 | SMN1; SMN2 (0.60) | RAB9ANPC1CTDSP1MAPTALDH1A1 | |
| Biphenyl SCHEMBL28809192 | 0.92 | SMN1; SMN2 (0.60) | RAB9ANPC1CTDSP1MAPTALDH1A1 | |
| SCHEMBL9452041 | 0.92 | SMN1; SMN2 (0.60) | RAB9ANPC1CTDSP1MAPTALDH1A1 | |
| SCHEMBL8723556 | 0.92 | SMN1; SMN2 (0.60) | RAB9ANPC1CTDSP1MAPTALDH1A1 | |
| Benzoyl Chloride SCHEMBL1241 | 0.92 | — | — | |
| Benzoyl Chloride SCHEMBL8995857 | 0.92 | CES1 (0.58) | MAPTALDH1A1CES2CES1TSHR | |
| SCHEMBL19185622 | 0.92 | CES1 (0.58) | MAPTALDH1A1CES2CES1TSHR | |
| Benzoyl Chloride SCHEMBL1331834 | 0.92 | — | — | |
| Benzoyl Chloride SCHEMBL14359354 | 0.92 | CES1 (0.58) | MAPTALDH1A1CES2CES1TSHR | |
| Biphenyl SCHEMBL8775397 | 0.90 | SMN1; SMN2 (0.58) | RAB9ANPC1CTDSP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834392-B2 | KDM4B inhibitors for the treatment of inflammatory diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2023-12-05 | — | — | US | disclosed |
| US-20220119344-A1 | KDM4B INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT D/B/A ZUCKER INSTITUTE FOR INNOVATION COMMERCIALIZATION | 2022-04-21 | — | — | US | disclosed |
| WO-2020247567-A1 | KDM4B INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2020-12-10 | — | — | WO | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, FH, DPYD | RAB9A 1436/4885KMO 570/4885NPC1 3171/4885 |
| US-20220119344-A1 | KDM4B INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND DISORDERS | KDM1B, KDM4B, KDM3B | RAB9A 3196/4885KMO 1354/4885NPC1 3175/4885 |
| US-11834392-B2 | KDM4B inhibitors for the treatment of inflammatory diseases and disorders | KDM1B, KDM4B, KDM3B | RAB9A 3196/4885KMO 1354/4885NPC1 3175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.