Biphenyl

Biphenyl

SCHEMBL28809192

O=C(Cl)c1ccc(-c2ccc(C(=O)Cl)cc2)cc1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.60
MAPT P10636 4/20 0.60
RAB9A P51151 3/20 0.56
NPC1 O15118 1/20 0.56
CTDSP1 Q9GZU7 1/20 0.56
L3MBTL1 Q9Y468 2/20 0.54
PTPN1 P18031 2/20 0.54
GSK3B P49841 1/20 0.54
LMNA P02545 3/20 0.52
CDC25B P30305 1/20 0.52
ATM Q13315 1/20 0.52
FFAR1 O14842 1/20 0.52
CYP1A2 P05177 1/20 0.52
HIF1A Q16665 1/20 0.52
HPGD P15428 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
ERCC5 P28715 1/20 0.50
FEN1 P39748 1/20 0.50
HAO1 Q9UJM8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9452041 1.00 SMN1; SMN2 (0.60) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
SCHEMBL8723556 1.00 SMN1; SMN2 (0.60) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
SCHEMBL14416 1.00 SMN1; SMN2 (0.60) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
Biphenyl SCHEMBL8775397 0.98 SMN1; SMN2 (0.58) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
SCHEMBL22064857 0.93 EGFR (0.60) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
Biphenyl SCHEMBL505047 0.92 RAB9A (0.52) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
Biphenyl SCHEMBL5701245 0.91 MAPT (0.64) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
SCHEMBL10635547 0.91 MAPT (0.64) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
SCHEMBL10670934 0.89 ALDH1A1 (0.52) SMN1; SMN2MAPTRAB9ANPC1CTDSP1
SCHEMBL727046 0.89 ALDH1A1 (0.52) SMN1; SMN2MAPTRAB9ANPC1CTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109891326-B Electrophotographic photoreceptor, process cartridge, and image forming apparatus 京瓷办公信息系统株式会社 2022-08-02 CN disclosed