Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
| ▸ | BTD | P43251 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664130 | 0.79 | CYP11B1 (0.35) | CYP11B2CYP11B1PGRGRM4CYP3A4 | |
| SCHEMBL13599735 | 0.72 | PGR (0.49) | CYP11B2CYP11B1CYP19A1PGROPRM1 | |
| SCHEMBL1131394 | 0.69 | KDM1A (0.34) | CYP11B2CYP11B1CYP19A1GRM4KDM1A | |
| SCHEMBL14264346 | 0.68 | CYP11B1 (0.34) | CYP11B2CYP11B1GRM4 | |
| SCHEMBL15313258 | 0.67 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL15311835 | 0.67 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL1179630 | 0.66 | CYP19A1 (0.46) | CYP11B2CYP11B1CYP19A1OPRM1OPRD1 | |
| SCHEMBL732031 | 0.64 | KDM1A (0.46) | CYP11B2CYP11B1CYP19A1PGRCYP17A1 | |
| SCHEMBL5045386 | 0.63 | CYP11B2 (0.43) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL8746223 | 0.62 | KDM1A (0.47) | CYP11B2CYP11B1CYP19A1PGRCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076784-A1 | Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors | NOVARTIS AG (CH) | 2008-03-27 | — | — | US | disclosed |
| CN-1968930-A | Bicyclic nitrogen-containing heterocycles as aromatase inhibitors | SPEEDEL EXPERIMENTA AG (CH) | 2007-05-23 | — | — | CN | disclosed |
| EP-1765777-A2 | BICYCLIC, NITROGEN-CONTAINING HETEROCYCLES AS AROMATASE INHIBITORS | Speedel Experimenta AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005118540-A2 | BICYCLIC, NITROGEN-CONTAINING HETEROCYCLES AS AROMATASE INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076784-A1 | Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors | CYP19A1, NR5A1, HSD17B11 | CYP11B2 6/4885CYP11B1 5/4885CYP19A1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.