Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15311835 | 1.00 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL15313292 | 1.00 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL15311959 | 0.76 | CYP11B1 (0.61) | CYP11B2CYP11B1 | |
| SCHEMBL5051697 | 0.67 | CYP11B2 (0.50) | CYP11B2CYP11B1 | |
| SCHEMBL19559619 | 0.63 | CYP11B2 (0.74) | CYP11B2CYP11B1 | |
| SCHEMBL15311885 | 0.63 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL13599735 | 0.63 | PGR (0.49) | CYP11B2CYP11B1 | |
| SCHEMBL15311513 | 0.62 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL26555703 | 0.61 | CYP11B2 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL15311779 | 0.61 | CYP11B2 (1.00) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838883-B1 | NEW PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-11-08 | — | — | EP | claimed |
| US-9187429-B2 | Phenyl-tetrahydroisoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-11-17 | — | — | US | claimed |
| EP-2838883-A1 | NEW PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-02-25 | — | — | EP | claimed |
| WO-2013156423-A1 | NEW PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-10-24 | — | — | WO | claimed |
| US-20130274287-A1 | PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-10-17 | — | — | US | claimed |
| EP-2838883-B1 | NEW PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-11-08 | — | — | EP | disclosed |
| US-9187429-B2 | Phenyl-tetrahydroisoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-11-17 | — | — | US | disclosed |
| EP-2838883-A1 | NEW PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013156423-A1 | NEW PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-10-24 | — | — | WO | disclosed |
| US-20130274287-A1 | PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274287-A1 | PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES | PRMT7, GNAQ, RECQL | CYP11B2 498/4885CYP11B1 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.