Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897946 | 0.81 | GPR119 (0.56) | GPR119CYP11B1CYP11B2CYP2C9KCNH2 | |
| SCHEMBL5189111 | 0.81 | GPR119 (0.51) | GPR119CYP11B1CYP11B2CYP2C9KCNH2 | |
| SCHEMBL2403930 | 0.81 | GPR119 (0.45) | GPR119CYP2C9KCNH2EGFR | |
| SCHEMBL6066093 | 0.76 | PIP4K2C (0.38) | GPR119EGFR | |
| SCHEMBL5052027 | 0.69 | GPR119 (0.38) | GPR119CYP11B1CYP11B2CYP2C9KCNH2 | |
| SCHEMBL388457 | 0.69 | GPR119 (0.62) | GPR119 | |
| SCHEMBL5140547 | 0.67 | GPR119 (0.69) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5046463 | 0.67 | GPR119 (0.55) | GPR119CYP2C9KCNH2 | |
| SCHEMBL386313 | 0.66 | GPR119 (0.67) | GPR119CYP2C9KCNH2 | |
| SCHEMBL1243274 | 0.66 | GPR119 (0.65) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-A1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005007647-A9 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005007647-A1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | disclosed |