Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.57 |
| ▸ | DNMT3B | Q9UBC3 | 3/20 | 0.57 |
| ▸ | PGK1 | P00558 | 3/20 | 0.55 |
| ▸ | PGK2 | P07205 | 3/20 | 0.55 |
| ▸ | NT5E | P21589 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202949 | 0.95 | ADORA1 (0.66) | ADORA1ADORA3ADORA2APGK1PGK2 | |
| SCHEMBL7202938 | 0.95 | ADORA1 (0.66) | ADORA1ADORA3ADORA2APGK1PGK2 | |
| SCHEMBL25090698 | 0.87 | ADORA3 (0.60) | ADORA1ADORA3ADORA2ANT5E | |
| SCHEMBL19366689 | 0.87 | ADORA3 (0.60) | ADORA1ADORA3ADORA2ANT5E | |
| SCHEMBL5062568 | 0.86 | ADORA1 (0.80) | ADORA1ADORA3ADORA2ADNMT1DNMT3B | |
| SCHEMBL5062524 | 0.84 | ADORA3 (0.73) | ADORA1ADORA3ADORA2APGK1PGK2 | |
| SCHEMBL5062641 | 0.84 | DNMT1 (0.52) | ADORA1ADORA3ADORA2ADNMT1DNMT3B | |
| SCHEMBL7203458 | 0.82 | PI4KA (0.53) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| SCHEMBL7203455 | 0.82 | PI4KA (0.53) | ADORA1ADORA3ADORA2API4KAPI4K2B | |
| SCHEMBL31201331 | 0.81 | ADORA1 (0.88) | ADORA1ADORA3ADORA2APGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | DNMT3B, DNMT1, DNMT3L | ADORA1 1009/4885ADORA3 708/4885ADORA2A 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.